The invention concerns the use of a piperazine derivative of formula (I)
##STR1##
wherein: A and B=C.dbd.O, C.dbd.S or CR.sub.7 R.sub.8 with R.sub.7 =H,
methyl, cyano, cyanomethyl, CO.sub.2 CH.sub.3 or (C.dbd.O)CH.sub.3 and
R.sub.8 =H or phenyl; R.sub.1 to R.sub.6 =H, OH, or C.sub.1 -C.sub.5
alkoxy; X represents: either C.dbd.O, O(C.dbd.O), O(C.dbd.S), O(SO.sub.2),
NH(C.dbd.O), NH(C.dbd.S), NH(SO.sub.2), S(C.dbd.O) or S(C.dbd.S), then
Y=NR.sub.9 R.sub.10, CR.sub.9 R.sub.10 R.sub.11 in which R.sub.9, R.sub.10
and R.sub.11 =H, C.sub.1 -C.sub.5 alkyl, C.sub.2 -C.sub.5 alkenyl, or
C.sub.2 -C.sub.5 alkynyl or Y=nitrogenous heterocycle comprising 5 to 10
atoms; or X represents O, S, O(C.dbd.O)O, NH(C.dbd.O)O, or S(C.dbd.O)O,
then Y=CR.sub.9 R.sub.10 R.sub.11 with R.sub.9, R.sub.10, R.sub.11 as
above; or one of its pharmaceutically acceptable salts for preparing a
medicine inhibiting HIV. The invention is useful for treating HIV
infection.
A invenção concerne o uso de um derivative do piperazine do ## do ## STR1 da fórmula (I) wherein: A e B=C.dbd.O, C.dbd.S ou CR.sub.7 R.sub.8 com R.sub.7 = H, methyl, cyano, cyanomethyl, CO.sub.2 CH.sub.3 ou (C.dbd.O)CH.sub.3 e R.sub.8 = H ou phenyl; R.sub.1 a R.sub.6 = H, OH, ou C.sub.1 - C.sub.5 alkoxy; X representam: um ou outro C.dbd.O, O(C.dbd.O), O(C.dbd.S), O(SO.sub.2), NH(C.dbd.O), NH(C.dbd.S), NH(SO.sub.2), S(C.dbd.O) ou S(C.dbd.S), então Y=NR.sub.9 R.sub.10, CR.sub.9 R.sub.10 R.sub.11 em que R.sub.9, R.sub.10 e R.sub.11 = H, C.sub.1 - C.sub.5 alkyl, C.sub.2 - alkenyl C.sub.5, ou C.sub.2 - alkynyl C.sub.5 ou heterocycle de Y=nitrogenous que compreende 5 a 10 átomos; ou X representa O, S, O(C.dbd.O)O, NH(C.dbd.O)O, ou S(C.dbd.O)O, então Y=CR.sub.9 R.sub.10 R.sub.11 com R.sub.9, R.sub.10, R.sub.11 como acima; ou um de seus sais pharmaceutically aceitáveis para preparar uma medicina que inibe o HIV. A invenção é útil para tratar a infecção de HIV.
