The present invention provides a composition for use in raising an immune
response directed against Porphyromonas gingivalis. The composition
includes a suitable adjuvant and/or acceptable carrier and one
substantially purified P. gingivalis immunogen. The immunogen is selected
from the group consisting of Antigen 1, Antigen 2, Antigen 3, Antigen 4
and epitope containing fragments thereof, in which: Antigen 1 is an
antigen of P. gingivalis and has an internal amino acid
sequence:DLENKGEATLLVTFGSSYKAPRETYAKIEKTFAAAYPDQR; Antigen 2 is an antigen
of P. gingivalis and has an internal amino acid sequence:
DNPDENPLEGDITQTHTEKYVLAED; Antigen 3 is an antigen of P. gingivalis and
has an internal amino acid sequence: DVLLLDVTPLSLGIETMGGVMTYLIDANTTIPKLK;
Antigen 4 is an antigen of P. gingivalis and has an internal amino acid
sequence: VYNASISAVGNTSAIDPVVQIIHHN.