DNA constructs and other compositions and methods for controlling gene expression in eukaryotic cells and organisms are derived from bacterial quorum sensing systems. One or more cis elements from the luxI promoter ("lux box") or a functionally similar sequence are incorporated in a eukaryotic promoter. A receptor protein from the LuxR family of transcriptional regulators, upon binding an acylated homoserine lactone (AHL) compound, interacts with the lux box, modulating the activity of the promoter.

Las construcciones de la DNA y otras composiciones y métodos para controlar la expresión del gene en células y organismos eukaryotic se derivan del quorum bacteriano que detecta sistemas. Unos o más elementos cis del promotor del luxI ("caja del lux") o de una secuencia funcionalmente similar se incorporan en un promotor eukaryotic. Una proteína del receptor de la familia de LuxR de los reguladores del transcriptional, sobre atar un compuesto acylated de la lactona del homoserine (AHL), obra recíprocamente con la caja del lux, modulando la actividad del promotor.

 
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