Simvastatin, a known anti-cholesterol drug, is used in effective doses over a period of time to reduce and sometimes cure cases of advanced malignant solid tumor. Examples of treatment of hepatocellular carcinoma and diffused metastatic colon carcinoma are described.

Simvastatin, una droga sabida del contra-colesterol, se utiliza en dosis efectivas durante hora de reducir y de curar a veces cajas de tumor sólido malo avanzado. Los ejemplos del tratamiento del carcinoma hepatocelular y del carcinoma metastatic difundido de los dos puntos se describen.
 
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< Hydrogenation process for the formation of 3,5-dihydro HMG-CoA reductase inhibitors

< DNA encoding triol polyketide synthase

> Mutant strains of Aspergillus terreus for producing 7-[1,2,6,7,8,8a(R)-hexa-hydro-2(S),6(R)-dimethyl-8(S)-hydroxy-1(S)-napht hyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid),I)

> Process to manufacture simvastatin and intermediates
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