2-Phenylpyran-4-one derivatives of formula (I):
##STR1##
wherein:
R.sup.1 represents an alkyl or --NR.sup.4 R.sup.5 group, wherein R.sup.4
and R.sup.5 each independently represents a hydrogen atom or an alkyl
group;
R.sup.2 represents an alkyl, C.sub.3 -C.sub.7 cycloalkyl, pyridyl, thienyl,
naphthyl, tetrahydronaphthyl or indanyl group, or a phenyl group which may
be unsubstituted or substituted by one or more halogen atoms or alkyl,
trifluoromethyl, hydroxy, alkoxy, methylthio, amino, mono- or
dialkylamino, hydroxalkyl or hydroxycarbonyl groups;
R.sup.3 represents a methyl, hydroxymethyl, alkoxymethyl, C.sub.3 -C.sub.7
cycloalkoxymethyl, benzyloxymethyl, hydroxycarbonyl, nitrile,
trifluoromethyl or difluoromethyl group or a CH.sub.2 --R.sup.6 group
wherein R.sup.6 represents an alkyl group; and
X represents a single bond, an oxygen atom, a sulfur atom or a methylene
group;
or pharmaceutically acceptable salts thereof, processes for their
production and synthetic intermediates used in said processes,
pharmaceutical compositions containing them and their use in medical
treatment.
derivados 2-Phenylpyran-4-one del fórmula (i): ## del ## STR1 en donde: R.sup.1 representa un alkyl o -- grupo de NR.sup.4 R.sup.5, en donde R.sup.4 y R.sup.5 cada uno representa independientemente a un átomo del hidrógeno o a grupo alkyl; R.sup.2 representa un alkyl, C.sub.3 - cycloalkyl C.sub.7, pyridyl, thienyl, la naftílico, el grupo del tetrahydronaphthyl o del indanyl, o un grupo fenilo que pueda ser sin sustituir o substituido por unos o más átomos del halógeno o grupos del alkyl, del trifluoromethyl, hydroxy, alkoxy, methylthio, amino, mono o del dialkylamino, del hydroxalkyl o del hydroxycarbonyl; R.sup.3 representa un metílico, hidroximetílico, alkoxymethyl, C.sub.3 - cycloalkoxymethyl C.sub.7, benzyloxymethyl, hydroxycarbonyl, nitrile, grupo del trifluoromethyl o del difluoromethyl o un CH.sub.2 -- el grupo R.sup.6 en donde R.sup.6 representa a grupo alkyl; y X representa un solo enlace, un átomo de oxígeno, un átomo del sulfuro o un grupo del metileno; o farmacéutico sales aceptables de eso, procesos para su producción e intermedios sintéticos usados en los procesos dichos, composiciones farmacéuticas que contienen los y su uso en el tratamiento médico.
