A new family of proteins having structural similarity to the baculovirus inhibitor of apoptosis protein (iap) are described. These ilp's (iap-like proteins) are distinguished by the presence of a RING finger domain and three baculovirus iap-like repeat motifs. Exemplified are sequences from Drosophila and human. Methods for the use of these proteins, and nucleic acids coding therefor, are provided. These methods include both the inhibition and stimulation of apoptosis in target cells.

Описана новая семья протеинов имея структурно сходство к иу АБС битор baculovirus протеина apoptosis (iap). Эти ilp's (иап-kak протеины) различены присутсвием домена перста КОЛЬЦА и baculovirus 3 иап-kak motifs повторения. Приведены в пример последовательности от дрозофилы и человека. Обеспечены методы для пользы этих протеинов, и нуклеиновые кислоты кодируя therefor. Эти методы вклюают и ингибитирование и стимулирование apoptosis в клетки цели.

 
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