A transgenic rabbit which has in its genomic DNA sequences that encode apolipoprotein (a) and apolipoprotein B polypeptides which are capable of combining to produce lipoprotein (a), a process for creating such a rabbit, and the use of the rabbit to identify compounds which are effective in the treatment of human diseases which are associated with, induced and/or exacerbated by Lp(a) expression.

Um coelho transgenic que tenha em suas seqüências genomic do DNA que codificam os polypeptides do apolipoprotein (a) e do apolipoprotein B que são capazes de combinar para produzir o lipoprotein (a), um processo para criar tal coelho, e o uso do coelho identificar os compostos que são eficazes no tratamento das doenças humanas que são associados com, induzido e/ou exacerbated pela expressão de Lp(a).