Antisense compounds, compositions and methods are provided for modulating the expression of Syntaxin 4 interacting protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Syntaxin 4 interacting protein. Methods of using these compounds for modulation of Syntaxin 4 interacting protein expression and for treatment of diseases associated with expression of Syntaxin 4 interacting protein are provided.