The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding human TR11, TR11SV1, and TR11SV2 receptors. TR11, TR11SV1, and TR11SV2 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR11, TR11SV1, and TR11SV2 receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of TR11, TR11SV1, and TR11SV2 receptors. Further provided are therapeutic methods for treating disease states related to aberrant proliferation and differentiation of cells which express the TR11, TR11SV1, and TR11SV2 receptors.

A invenção atual relaciona-se aos membros da novela da família do fator do necrosis do tumor dos receptors. A invenção fornece as moléculas isoladas do ácido nucleic que codificam os receptors TR11, TR11SV1, e TR11SV2 humanos. Os polypeptides TR11, TR11SV1, e TR11SV2 são fornecidos também, como são vetores, as pilhas de anfitrião e os métodos recombinant para produzir o mesmo. A invenção mais adicional relaciona-se aos métodos de seleção para identificar os agonists e os antagonistas da atividade do receptor TR11, TR11SV1, e TR11SV2. São fornecidos também os métodos diagnósticos para detectar os estados da doença relacionados à expressão aberrant dos receptors TR11, TR11SV1, e TR11SV2. São fornecidos mais mais os métodos therapeutic para tratar os estados da doença relacionados ao proliferation e ao differentiation aberrant das pilhas que expressam os receptors TR11, TR11SV1, e TR11SV2.