An image forming apparatus includes an image bearing body, a surface of which includes a photosensitive body having a hardness in the range of 100 to 500 (N/mm.sup.2), a charging device, which includes magnetic charging particles and is in friction contact with the image bearing body charges the image bearing body. A supporting member holds the magnetic charging particles with a magnetic force. An exposing device forms an electrostatic image by image exposing the image bearing body, which is charged by the charging means. A developing device develops the electrostatic image on the image bearing body. A transfer device transfers a developed image onto a transfer material and is in pressure contact with the image body. A pressure of the transfer material to the image bearing body is not less than 1 g/cm and not more than 100 g/cm in line pressure.

 
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> Substituted alpha-hydroxy acid caspase inhibitors and the use thereof

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~ 00054