Method for the prevention or treatment of pruritus with anti-pruritic compounds is provided. The compounds of formulae I, II, IIA, III, IIIA, IV and IVA have the structure: ##STR1## ##STR2## wherein R.sup.1, R.sub.2, R.sub.3, R.sup.4 ; and X, X.sub.4, X.sub.5, X.sub.7, X.sub.9 ; Y, Z and n are as described in the specification.

Обеспечен метод для предохранения или обработки почесухи с противозудными смесями. Смеси формул ii1, II, IIA, III, IIIA, iv и IVA имеют структуру: ## ## STR1 ## ## STR2 при котором R.sup.1, R.sub.2, R.sub.3, R.sup.4; и х, X.sub.4, X.sub.5, X.sub.7, X.sub.9; Ы, з и н как описано в спецификации.

 
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