In accordance with the present invention, there are provided humanized fish insulin genes. Humanized insulin the present invention encode human insulin alpha and/or beta chains while using fish-preferred codons and regulatory sequences. These humanized genes are thus expressible in fish islet cells. Also provided are transgenic fish having islet cells containing and capable of expressing humanized insulin genes. These islet cells (Brockmann Bodies) can be xenotransplanted into subjects having diabetes. In this manner normoglycemia can be achieved in the recipient of the islets.

De acordo com a invenção atual, é fornecido humanized genes do insulin dos peixes. O insulin humanized a invenção atual codifica o alfa humano do insulin e/ou correntes beta ao usar codons peixe-preferidos e seqüências regulatory. Estes genes humanized são assim expressible em pilhas do islet dos peixes. São fornecidos também os peixes transgenic que têm pilhas do islet conter e capaz de expressar genes humanized do insulin. Estas pilhas do islet (corpos de Brockmann) podem ser xenotransplanted nos assuntos que têm o diabetes. Nesta maneira o normoglycemia pode ser conseguido no receptor dos islets.