Synthetic processes are provided wherein mixed backbone oligomeric compounds are prepared having at least one phosphodiester internucleoside linkage in addition to one or more phosphorothioate, phosphoramidate and boranophosphate internucleoside linkages. Novel H-phosphonate intermediates are also disclosed that are useful in the synthetic processes. The synthetic processes use a novel oxidation step to oxidize H-phosphonate internucleoside linkages to phosphodiester internucleoside linkages without degradation of adjacent phosphorothioate, phosphoramidate and boranophosphate internucleoside linkages. Also provided are synthetic intermediates useful in such processes.

Os processos sintéticos são fornecidos wherein os compostos oligomeric da espinha dorsal misturada são preparados tendo ao menos um enlace do internucleoside do phosphodiester além enlaces do internucleoside de um ou mais phosphorothioate, de phosphoramidate e de boranophosphate. Os intermediários de H-phosphonate da novela são divulgados também que são úteis nos processos sintéticos. Os processos sintéticos usam uma etapa da oxidação da novela oxidar enlaces do internucleoside de H-phosphonate aos enlaces do internucleoside do phosphodiester sem degradação de enlaces adjacentes do internucleoside do phosphorothioate, do phosphoramidate e do boranophosphate. São fornecidos também os intermediários sintéticos úteis em tais processos.