The invention provides cDNA which encode Ndr2-related proteins. It also provides for the use of the cDNAs, fragments, complements, and variants thereof and of the encoded proteins, portions thereof and antibodies thereto for diagnosis and treatment of cancer, particularly cancers of the intestine, breast, uterus, liver, brain, and kidney. The invention additionally provides expression vectors and host cells for the production of the proteins and a transgenic model system.

A invenção fornece o DNA que codificam proteínas de Ndr2-related. Fornece também para o uso do DNAS, dos fragmentos, dos complementos, e dos variants disso e das proteínas, das parcelas disso e dos antibodies a isso para o diagnóstico e do tratamento codificados do cancer, particularmente cancers do intestine, peito, uterus, fígado, cérebro, e kidney. A invenção fornece adicionalmente vetores da expressão e pilhas de anfitrião para a produção das proteínas e de um sistema modelo transgenic.

 
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