Preparations of pyrophosphate analogues, including phosphonoformic acid, bisphosphonic acid, and phosphonoacetic acid derivatives, exhibiting antiviral activity. Such compounds, are used directly, or as prodrugs, in compositions and methods for treating viral infections, including but not limited to HIV, herpesviruses including HSV, EBV, VZV, CMV, HHV-6 and HHV-8 (Kaposi's sarcoma); HPV; rhinoviruses; and hepatitis-linked viruses. Compounds of the present invention for use as antiviral agents or their intermediates include sulfur-containing, polyhydroxy, and lipophilic derivatives of phosphonoformic acid.

Preparações de analogues do pyrophosphate, including o ácido phosphonoformic, ácido bisphosphonic, e derivatives ácidos phosphonoacetic, exibindo a atividade antiviral. Tais compostos, são usados diretamente, ou como prodrugs, nas composições e nos métodos tratando infecções viral, incluindo mas não limitados ao HIV, aos herpesviruses including HSV, ao EBV, ao VZV, a CMV, a HHV-6 e a HHV-8 (sarcoma de Kaposi); HPV; rhinoviruses; e vírus hepatitis-ligados. Os compostos da invenção atual para o uso como agentes antiviral ou seus intermediários incluem derivatives sulfur-containing, polyhydroxy, e lipophilic do ácido phosphonoformic.