The present provides a mammal in which the expression of one or more interleukin genes has been suppressed. More specifically, the invention concerns the inactivating deletion of the interleukin-1 receptor antagonist gene to produce a knock-out non-human mammal with decreased or completely suppressed expression of the endogenous gene. The invention provides methods for preparing such knock-out mammals and methods of using the knock-out mammals to evaluate the effectiveness of therapeutic agents and regimens to treat diseases or disorders associated with perturbations in the interleukin pathways.

O presente fornece um mamífero em que a expressão de um ou mais genes do interleukin foi suprimida. Mais especificamente, a invenção concerne o apagamento inactivating do gene do antagonista do receptor interleukin-1 para produzir um mamífero non-human do knock-out com expressão diminuída ou completamente suprimida do gene endogenous. A invenção fornece métodos preparando tais mamíferos do knock-out e métodos de usar os mamíferos do knock-out avaliar a eficácia de agentes therapeutic e de regimens para tratar as doenças ou os disorders associadas com os perturbations nos pathways do interleukin.

 
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