Psoralen compound compositions are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which yet permit their binding to nucleic acid of pathogens. Reaction conditions that photoactivate these bound psoralens result in covalent crosslinking to nucleic acid, thereby inactivating the pathogen. Higher psoralen binding levels and lower mutagenicity results in safer, more efficient, and reliable inactivation of pathogens. In addition to the psoralen compositions, the invention contemplates inactivating methods using the new psoralens.

De de samenstellingssamenstellingen van Psoralen zijn samengesteld die substituties op 4..4 '..5 ' hebben, en 8 posities van psoralen, die nog hun band aan nucleic zuur van ziekteverwekkers toelaten. De voorwaarden dat van de reactie photoactivate deze psoralens resultaat in het covalente crosslinking aan nucleic zuur bonden, daardoor buiten werking stellend de ziekteverwekker. Hoger psoralen bindende niveaus en lagere mutageen karakterresultaten in veiligere, efficiƫntere, en betrouwbare inactivering van ziekteverwekkers. Naast psoralen samenstellingen, overweegt de uitvinding buiten werking stellend methodes gebruikend nieuwe psoralens.

 
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