The present invention relates to compounds of formula 1 ##STR1## and pharmaceutically acceptable salts and solvates thereof wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, and Z are as defined herein. The invention also relates to pharmaceutical compositions comprising compounds of formula 1 and to methods of inhibiting abnormal cell growth, including cancer, in a mammal by administering compounds of formula 1 to the mammal. The invention also relates to intermediates and methods useful in synthesizing compounds of formula 1.

A invenção atual relaciona-se aos compostos do ## do ## STR1 da fórmula 1 e pharmaceutically de sais e de solvates aceitáveis disso wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, e Z são como definidos nisto. A invenção relaciona-se também às composições pharmaceutical que compreendem compostos da fórmula 1 e aos métodos de inibir o crescimento anormal da pilha, including o cancer, em um mamífero administrando compostos da fórmula 1 ao mamífero. A invenção relaciona-se também aos intermediários e aos métodos úteis em synthesizing compostos da fórmula 1.

 
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