Novel compounds that are potent inhibitors of HIV reverse transcriptase (RT) are described in the invention. The novel compounds also inhibit replication of a retrovirus, such as human immunodeficiency virus-1 (HIV-1). The novel compounds of the invention include analogs and derivatives of phenethylthiazolylthiourea (PETT), of dihydroalkoxybenzyloxopyrimidine (DABO), and of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT). The invention additionally provides a composite HIV reverse-transcriptase (RT) nonnucleoside inhibitor (NNI) binding pocket constructed from a composite of multiple NNI-RT complexes The composite RT-NNI binding pocket provides a unique and useful tool for designing and identifying novel, potent inhibitors of reverse transcriptase.

Смеси романа будут potent иами АБС битор transcriptase hiv обратного (rt) описаны в вымысле. Смеси романа также блокируют репликацию retrovirus, such as людской иммунодефицит virus-1 (HIV-1). Смеси романа вымысла вклюают аналоги и производные phenethylthiazolylthiourea (PETT), dihydroalkoxybenzyloxopyrimidine (DABO), и 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT). Вымысел дополнительн обеспечивает составной и АБС битор nonnucleoside hiv obratny1-transcriptase (rt) (NNI) binding, котор карман построил от смеси множественных комплексов NNI-RT составной карман RT-NNI binding обеспечивает уникально и полезный инструмент для конструировать и определять роман, potent иы АБС битор обратного transcriptase.