Novel methods, processes and metal complexes attached to a hypoxia-localizing moiety comprising a metal, preferably radionuclide of rhenium or technetium; a hypoxia-localizing moiety; and, a complexing ligand, wherein said ligand and said radionuclide combined have cell membrane permeabilities greater than that of sucrose, are disclosed.

Métodos de la novela, procesos y complejos del metal unidos a un moiety hypoxia-que localiza que abarca un metal, preferiblemente radionuclide del renio o technetium; un moiety hypoxia-que localiza; y, se divulga un ligand complexing, en donde el ligand dicho y el radionuclide dicho combinados tienen permeabilities de la membrana de la célula mayores que el de la sucrosa.