Two distinct scavenger receptor type proteins having high affinity for modified lipoproteins and other ligands have been isolated, characterized and cloned. HaSR-BI, an AcLDL and LDL binding scavenger receptor, which is distinct from the type I and type II macrophage scavenger receptors, has been isolated and characterized and DNA encoding the receptor cloned from a variant of Chinese Hamster Ovary Cells, designated Var-261. dSR-CI, a non-mammalian AcLDL binding scavenger receptor having high ligand affinity and broad specificity, was isolated from Drosophila melanogaster. The isolated receptors are useful in screening for drugs that inhibit uptake of cholesterol in endothelial or adipose cells or macrophages, respectively. They are also useful as probes for the isolation of other lipoprotein receptors and in research the roles of these receptors.

O tipo distinto proteínas do receptor do limpador dois que têm a afinidade elevada para lipoproteins modificados e outros ligands foram isolados, caracterizados e cloned. O HaSR-haSR-BI, um AcLDL e o receptor obrigatório do limpador de LDL, que é distinto do tipo I e do tipo receptors do limpador do macrophage de II, foram isolados e caracterizados e DNA que codifica o receptor cloned de um variant de pilhas chinesas do ovary do hamster, designado Var-261. dSR-CI, um receptor obrigatório non-non-mammalian do limpador de AcLDL que tem a afinidade elevada do ligand e o specificity largo, foram isolados do melanogaster da drosófila. Os receptors isolados são úteis em selecionar para as drogas que inibem o uptake do cholesterol em pilhas ou em macrophages endothelial ou adipose, respectivamente. São também úteis como pontas de prova para a isolação de outros receptors do lipoprotein e na pesquisa os papéis destes receptors.

 
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