Two classes of polypeptides derived from human IgE are described. One class
binds selectively to the high affinity IgE receptor on mast cells and
basophils, but not to the low affinity IgE receptor on B-cells, monocytes,
eosinophils and platelets. The other class binds to the low affinity
receptor, but not the high affinity receptor. The differential binding
polypeptides of this invention are useful in diagnostic procedures for IgE
receptors or in the therapy of IgE-mediated disorders such as allergies.
They also are useful in preparing antibodies capable of binding regions of
IgE that participate in receptor binding.