The invention provides an improved method for the delivery and stabilization of antisense oligodeoxynucleotides (ODNs) to cells. The unmodified ODNs are complexed to a polynuclear platinum compound or to a structural derivative thereof. Complexation neutralizes the charge of the ODN and makes possible its passage into the cell, without the addition of other transfection agents. The invention may be used in the treatment any disease which is amenable to treatment by antisense ODNs. In addition, the invention provides a new method specifically for the treatment of cancer.

Вымысел снабубежит улучшенный метод для поставки и стабилизации oligodeoxynucleotides antisense (ODNs) клетки. Unmodified ODNs complexed к полинуклеаровой смеси платины или к структурно производному thereof. Комплексование нейтрализует обязанность ODN и делает по возможности свой проход в клетку, без добавления других веществ transfection. Вымысел может быть использован в обработке любое заболевание согласно к обработке antisense ODNs. In addition, вымысел обеспечивает новый метод специфически для обработки рака.

 
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