Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenases, stromelysins and gelatinases. TNF-.alpha. converting enzyme (TACE), a pro-inflammatory cytokine, catalyzes the formation of TNF-.alpha. from membrane bound TNF-.alpha. precursor protein. It is expected that small molecule inhibitors of MMPs and TACE therefore have the potential for treating a variety of disease states. The present invention provides low molecular weight, non-peptide inhibitors of matrix metalloproteinases (MMPs) and TNF-.alpha. converting enzyme (TACE) for the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection having the formula ##STR1## wherein R.sup.2 and R.sup.3 form a heterocyclic ring and A is S, S(O), or S(O).sub.2, and R.sup.1 and R.sup.4 are defined herein.

Os metalloproteinases da matriz (MMPs) são um grupo dos enzymes que foram implicados na destruição pathological das membranas do tecido conexivo e do porão. Estes zincam conter endopeptidases consistem em diversos subconjuntos dos enzymes including collagenases, stromelysins e gelatinases. O enzyme convertendo-se de TNF-.alpha. (TACE), um cytokine pro-pro-inflammatory, catalyzes a formação de TNF-.alpha. de proteína encadernada do precursor da membrana TNF-.alpha.. Espera-se que os inibidores pequenos da molécula de MMPs e de TACE têm conseqüentemente o potencial para tratar uma variedade de estados da doença. A invenção atual fornece o peso molecular baixo, os inibidores do non-non-peptide de metalloproteinases da matriz (MMPs) e do enzyme convertendo-se de TNF-.alpha. (TACE) para o tratamento do arthritis, o metastasis do tumor, o ulceration do tecido, a ferida anormal que healing, a doença peridental, a doença do osso, o diabetes (resistência de insulin) e a infecção de HIV que tem o ## do ## STR1 da fórmula wherein R.sup.2 e R.sup.3 dão forma a um anel heterocyclic e A é S, S(O), ou S(O).sub.2, e R.sup.1 e R.sup.4 são definidos nisto.

 
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