Compositions and methods are provided for inhibiting the expression of
human tumor necrosis factor-.alpha.-converting enzyme (TACE). Antisense
oligonucleotides targeted to nucleic acids encoding TACE are preferred.
Methods of using these oligonucleotides for inhibition of TACE expression
and for treatment of diseases, particularly inflammatory and autoimmune
diseases, associated with overexpression of TACE or TNF-.alpha. are