The present invention relates, first, to methods and compositions for the modulation of acid sphingomyelinase (ASM)-related processes, including apoptosis. Such apoptosis can include, but is not limited to, environmental stress-induced apoptosis such as, for example, ionizing radiation and/or chemotherapeutic agent-induced apoptosis. Apoptosis can be characterized by a cellular morphology comprising cellular condensation, nuclear condensation or zeiosis. The present invention further relates to methods for the identification of compounds which modulate (i.e., either increase or decrease) sensitivity to ASM-related processes, including apoptosis.

La presente invenzione si riferisce, prima, ai metodi ed alle composizioni per la modulazione dello sphingomyelinase acido (processi ASM)-relativi, compreso il apoptosis. Tale apoptosis può includere, ma non essere limitato a, apoptosis stress-induced ambientale come, per esempio, radiazione ionizzante e/o apoptosis agente-indotto chemioterapeutico. Apoptosis può essere caratterizzato da una morfologia cellulare che contiene la condensazione cellulare, la condensazione nucleare o lo zeiosis. La presente invenzione ulteriore si riferisce ai metodi per l'identificazione dei residui che modulano (cioè, aumento o diminuzione) la sensibilità ai processi ASM-RELATIVI, compreso il apoptosis.

 
Web www.patentalert.com

< (none)

< Diagnostic assay for the modified nucleosides pseudouridine, 7-methyladenosine, or 1-methyladenosine

> Method of preparing an extract potent in anti-inflammation and anti-platelet aggregation from Zingiber officinale and pharmaceutical compositions containing said extract

> (none)

~ 00012