The present invention describes a non-human transgenic mouse that produces in its leukocytes, a recombinant human leukotriene B.sub.4 receptor (BLTR), having physiological activity of human BLTR. The transgenic mouse has stably integrated into its genome an exogenous gene construct which includes (A) 5' expression regulating sequences, including a BLTR specific promoter, (B) DNA encoding the BLTR and a signal sequence effective in directing overexpression of the BLTR into leukocytes of the transgenic mouse and (C) 3' regulatory sequences that result in the overexpression of the DNA in the leukocytes. In one embodiment, (A), (B), and (C) are operably linked in the gene construct to obtain production of the BLTR in the leukocytes and overexpression thereof in the transgenic mouse.

A invenção atual descreve um rato transgenic non-human que produza em seus leukocytes, um receptor humano recombinant do leukotriene B.sub.4 (BLTR), tendo a atividade physiological de BLTR humano. O rato transgenic integrou estàvel em seu genome uma construção exogenous do gene que incluísse (A) as seqüências regulando da expressão de 5', including um promoter específico de BLTR, (B) o DNA que codificam o BLTR e uma seqüência do sinal eficazes em dirigir o overexpression do BLTR em leukocytes do rato transgenic e (C) as seqüências regulatory de 3' que resultam no overexpression do DNA nos leukocytes. Em uma incorporação, (a), (b), e (C) são ligados operably na construção do gene para obter a produção do BLTR nos leukocytes e do overexpression disso no rato transgenic.