Compounds having Formula 1 wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to treatment by retinoids. ##STR1##

Combina ter a fórmula 1 wherein os símbolos têm o meaning definido na especificação são inibidores do enzyme do cytochrome P450RAI (inducible ácido retinoic), e são usados para as doenças de tratamento responsivas ao tratamento por retinoids. ## do ## STR1