Transgenic mice are described which serve as a model for Hepatitis C infection. The transgenic mice contain, in their germline and somatic cells, the Hepatitis C viral fragment CN2, N24 or CR under the control of a Cre-loxP switch-expression system. Administration of Cre to the mice results in a phenotype of increased serum GTP levels, emergence of acidophilic bodies in the liver, exfoliation of hepatic cells, hypertrophy and hyperplasia of Kupffer's cells, and conglomeration of lymphocytes.

Os ratos de Transgenic são descritos que servem como um modelo para a infecção do hepatitis C. Os ratos transgenic contêm, em seus germline e pilhas somatic, o fragmento viral CN2 do hepatitis C, N24 ou CR sob o controle de um sistema da interruptor-expressão de Cre-loxP. A administração de Cre aos ratos resulta em um phenotype de níveis aumentados do serum GTP, no emergence de corpos acidophilic no fígado, no exfoliation de pilhas hepatic, no hypertrophy e na hiperplasia de pilhas de Kupffer, e de conglomeração dos lymphocytes.

 
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