Chemical conjugates which comprise oligopeptides, having amino acid sequences that are selectively proteolytically cleaved by free prostate specific antigen (PSA) and known cytotoxic agents are disclosed. The conjugates of the invention are characterized by a diamine linker between the oligopeptide and vinblastine. Such conjugates are useful in the treatment of prostatic cancer and benign prostatic hypertrophy (BPH).

El producto químico conjuga que abarcan los oligopeptides, tener secuencias del aminoácido que proteolytically sean hendidas selectivamente por el antígeno específico de la próstata libre (PSA) y se divulgan los agentes citotóxicos sabidos. Las conjugaciones de la invención son caracterizadas por un linker de la diamina entre el oligopeptide y el vinblastine. Tales conjugaciones son útiles en el tratamiento del cáncer prostatic y de la hipertrofia prostatic benigna (BPH).

 
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